Distaclor®

Distaclor (Cefaclor) is a broad spectrum antibiotic which belongs to the cephalosporin group of antibiotics. In the main it is used for treatment of respiratory,urinary tract and soft tissue bacterial infections. Distaclor's mode of operation is by interfering with the ability of the bacteria to form and maintain cell wall integrity.

Approximately 10% of penicillin-sensitive patients will also display similar allergy symptoms to Distaclor, whilst this family of drugs may also increase the anti-coagulant effects of Warfarin. Antacids may also reduce the absorption of Distaclor and should not be taken in conjunction with this treatment.

In particular Distaclor is indicated in the treatment of the following infections when caused by susceptible strains of the designated organisms:

Acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase producing strains), Haemophilus parainfluenzae, Moraxella catarrhalis (including beta-lactamase producing strains), and Staphylococcus aureus.

Pharyngitis and tonsillitis caused by Streptococcus pyogenes (group A streptococci).

Pneumonia caused by S. pneumoniae, H. influenzae (including beta-lactamase producing strains), and M. catarrhalis (including beta-lactamase producing strains).

Uncomplicated lower urinary tract infections, including cystitis and asymptomatic bacteriuria, caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Staphylococcus saprophyticus.

Skin and skin structure infections caused by S. pyogenes (group A streptococci), S. aureus (including beta-lactamase producing strains), and Staphylococcus epidermidis (including beta-lactamase producing strains).

Bacteriological studies, to determine the causative organism and its susceptibility to cefaclor, should be performed. Therapy may be started while awaiting the results of these studies. Once these results become available, antimicrobial therapy should be adjusted accordingly.

Note: Distaclor MR is generally effective in the eradication of streptococci from the oropharynx. However, data establishing the efficacy of this antibiotic in the subsequent prevention of rheumatic fever are not available.
 

Distaclor is for oral administration in the following forms: -

Distaclor (Cefaclor) Capsules 500mg
Distaclor (Cefaclor) MR Tablets 375mg
Distaclor (Cefaclor) Suspension 125mg/5ml & 250mg/5ml